GLP-1 Agonists and Hair Loss

GLP-1 Agonists, including Ozempic, Monjurno, Wegovy, and Zepound, are among the most significant breakthroughs in weight loss and obesity medicine. These medications are widely discussed due to their ability to alter appetite and perception of food, leading to substantial weight loss and reductions in morbidity and mortality associated with obesity. Studies show a potential weight loss of up to 20% of total body weight within one year, compared to 7-10% achieved with traditional weight loss medications.

How GLP-1 Agonists Work

These medications stimulate hormones in the gut and brain, making you feel full faster and reducing hunger. The result is appetite suppression and often rapid weight loss. However, rapid weight loss can lead to hair shedding and loss, a condition known as Telogen Effluvium.

Understanding Telogen Effluvium

Telogen effluvium occurs when a major stressor to the body causes hairs in the resting phase to fall out simultaneously. Rapid weight loss and calorie reduction are considered significant stressors. Without sufficient calories and nutrients, hair growth cannot be sustained.

It is important to note that telogen effluvium is not specific to GLP-1 agonists but can occur with any form of rapid weight loss. Patients undergoing gastric bypass surgery or suffering from anorexia nervosa often experience similar hair loss. In clinical trials for Wegovy, 3% of participants reported hair loss, compared to 1% in the placebo group. However, in my practice within dermatology and obesity medicine, I find hair loss more common, with approximately 55% of my patients on these medications reporting hair loss or changes in hair texture.

Causes of Hair Loss on GLP-1 Agonists

Rapid weight loss significantly reduces calories and nutrients necessary for healthy hair. This can result in textural changes such as hair breakage and brittleness. Key macro- and micronutrients essential for hair health include:

• Protein
• Vitamin D
• Iron
• Zinc

Recommendations to Support Hair Health During GLP-1 Agonist Treatment

1. Increase Protein Intake:
   Consuming sufficient protein is critical. Aim for 90-100 grams of protein per day, starting before hair loss occurs as a preventive measure.

2. Optimize Nutrient Levels:
   Check and maintain optimal levels of key nutrients:

• Vitamin D (recommend 5000 IU daily, preferably with K2)

• Iron

• Zinc

3. Start a Hair Supplement:
   Begin supplementation proactively to prevent hair loss. I recommend Wellbel for GLP-1-associated hair loss due to its unique formulation, which includes:

• Betaine HCL: Enhances nutrient absorption and reduces bloating and gas, common side effects of GLP-1 agonists.

• Methylsulfonylmethane (MSM): Provides sulfur for healthy collagen and hair texture.

• Saw Palmetto: A natural inhibitor of DHT, the hormone that promotes hair loss in androgenic alopecia. Many patients with telogen effluvium also have underlying androgenic alopecia, which can be unmasked during shedding periods, leading to significant baldness and scalp show.

• Vitamin D, B12, and Folate: Essential for maintaining healthy hair, especially when food intake is reduced due to GLP-1 agonists.

4. Choose Non-Nauseating Supplements:
   Since GLP-1 agonists can cause nausea, it’s crucial to select hair supplements that do not exacerbate gastrointestinal distress. Wellbel is specifically formulated to avoid contributing to nausea or GI discomfort.

Conclusion

GLP-1 agonists can be life-changing for patients struggling with obesity. However, the associated hair loss can be dramatic and distressing. Implementing the above recommendations can help maintain hair health during treatment and support overall well-being. Start these measures proactively to protect your hair as you embark on your weight loss journey.